Testosterone Regulates Bone Response to Inflammation

Resistin Response to Inflammation

Highly active antiretroviral therapy (HAART) for the treatment of individuals infected by HIV-1 is limited by high costs, drug resistance, and drug-related toxicities. This has led researchers to investigate new treatment options, including ways to boost immune responses to better control HIV. One such approach has been termed supervised treatment interruption (STI)—in which HAART is intermitte...

The cAMP response element modulator (CREM) regulates TH2 mediated inflammation

A characteristic feature of allergic diseases is the appearance of a subset of CD4+ cells known as TH2 cells, which is controlled by transcriptional and epigenetic mechanisms. We aimed to analyze the role of CREM, a known transcriptional activator of T cells, with regard to TH2 responses and allergic diseases in men and mice. Here we demonstrate that T cells of asthmatic children and PBMCs of a...

Morphine Attenuates Testosterone Response to Central Injection of Kisspeptin in Male Rats

Bone – Inflammation

Figure Legend: Figure 1 Bone Inflammation, Chronic in the bone of a male F344/N rat from a chronic study. Bone resorption is associated with inflammation. Figure 2 Bone Inflammation, Chronic in a male B6C3F1/N mouse from a chronic study. Inflammatory cells surround a piece of bone that is undergoing resorption (sequestrum). Figure 3 Bone Inflammation, Chronic in a male F344/N rat from a chronic...

miR-320 regulates inflammation in EAE through interference with TGF-β signaling pathway

Background: MicroRNAs are small noncoding RNAs that regulate gene expression and involve in many cellular and physiological mechanisems. Recent studies have revealed that dysregulation of microRNAs might contribute to autoimmune disorders such as multiple sclerosis. Based on these findings, we examined the potential role of miR-320 isoforms, miR-320-3p and miR-320-5p, in the context of autoimmu...